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Bill Gates has Schizoid Personality Disorder [SPD] but continues to change the world. Others:

 

Isaac Asimov 

Jacob Bronowski

Charles Darwin

Bobby Fischer

Sigmund Freud

Stephen Hawking

Alfred Hitchcock

Theodore Kaczynski

David Keirsey

Doris Lessing

Karl Marx

Claudio Naranjo

Isaac Newton

Cynthia Ozick

Ezra Pound

B. F. Skinner

James Watson

Simone Weil

Some prefer the term Solitary Personality Type [SPT].